Do not use Analgin in the following cases:
- If you are allergic (hypersensitive) to the active substance metamizole, to other pyrazolone derivatives or to any of the other ingredients of the product;
- If you suffer from acute liver porphyria (an inherited disease with impaired red blood cell production) or congenital glucose-6-phosphate dehydrogenase deficiency (an inherited disease with a deficiency of this enzyme);
- If you have severe liver and / or kidney disease;
- If you have impaired bone marrow function (after cytostatic treatment) or blood disorders such as: aplastic anemia, a decrease in the number of blood cells, which leads to weakness, bruising or an increased likelihood of infection), agranulocytosis (a sharp decrease in the number of white blood cells, which increases the likelihood of infections), leukopenia (a decrease in the total number of white blood cells);
- Children under 10 years of age;
- Pregnancy and breast-feeding.
Take special care with Analgin
- If you are allergic to painkillers or antirheumatic drugs, other medicines or foods;
- In allergic bronchial asthma (attack of shortness of breath);
- If you know that you have a disease with a decrease in the number of white blood cells (leukocytes);
- If you have kidney or liver problems;
- If you have low blood pressure.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Concomitant use of metamizole and chlorpromazine (a medicine used to treat mental illness) can lead to a sharp drop in body temperature. Concomitant use of metamizole and coumarin anticoagulants, such as acenocoumarol and warfarin (medicines that reduce blood clotting), should be avoided.
- Metamizole reduces the effect of cyclosporine (a medicine used after organ transplantation and to treat tumors).
- Chloramphenicol and other myelotoxic products (medicines that damage the blood) increase the risk of side effects from the hematopoietic system when used together with metamizole. Do not use simultaneously Analgin with hypnotics, drugs for the treatment of depression, contraceptives, analgesics, allopurinol (for the treatment of gout).
- Metamizole may interact with captopril (for the treatment of heart disease and high blood pressure), lithium (for the treatment of mental illness), methotrexate (for the treatment of rheumatic and tumor diseases), and alter the effect of antihypertensive (lowering blood pressure) products and diuretics (dehydrating).
Pregnancy and breast-feeding
Ask your doctor or pharmacist for advice before taking any medicine.
The use of the product during pregnancy is not recommended.
The use of the product during breast-feeding is undesirable. In cases of emergency use, breast-feeding should be discontinued.
Driving and using machines
When taking high doses of Analgin, it is not recommended to drive or use machines that require active attention, as it may adversely affect attention and impair reactions in unexpected situations.
The following side effects may occur with the use of Analgin:
- Uncommon (affects less than 1 in 100 people):
Skin rash, low blood pressure, heart rhythm problems (fast or irregular heartbeat).
- Rare (affects less than 1 in 1,000 people):
Leukopenia (decreased white blood cell count, which increases the chance of infection); maculopapular rash (formation of skin plaques and nodules); hypersensitivity reactions (anaphylactic or anaphylactoid reactions) – itching, burning, redness of the skin, urticaria, edema (generalized or local), difficulty breathing and rarely gastrointestinal complaints, angioedema (including laryngeal), cardiac disorders, cardiac disorders pressure; kidney damage such as the appearance of protein in the urine, decreased or increased urine output, inflammation of the kidneys.
- Very rare (affects less than 1 in 10,000 people):
Agranulocytosis (severe reduction in the number of white blood cells, which increases the chance of infections). Typical signs of agranulocytosis include inflammatory changes in the skin and mucous membranes of the mouth, throat, genitals, sore throat and fever. In case of sudden deterioration of the general condition, if the fever does not decrease or reappears, in case of painful changes in the mucous membranes and skin, stop the use of Analgin and consult a doctor.
- Very rarely, thrombocytopenia may also occur (a decrease in the number of platelets, which increases the risk of bleeding or bruising); hemolytic anemia (reduction in the number of red blood cells, which can lead to pale or yellowing of the skin, weakness or shortness of breath); aplastic anemia (a sharp decrease in the number of blood cells, which leads to weakness, bruising or an increased likelihood of infection); asthma attack (in patients with analgesic asthma); Stevens-Johnson or Lyell syndrome (severe reaction accompanied by blistering of the skin, mouth, eyes and genitals); circulatory shock.
- Not known: nausea, vomiting, abdominal pain and discomfort, in rare cases ulceration or bleeding from the lining of the gastrointestinal tract. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.